Moment-based representation of the diffusion inside the brain from reduced DMRI acquisitions: Generalized AMURA

TitleMoment-based representation of the diffusion inside the brain from reduced DMRI acquisitions: Generalized AMURA
Publication TypeJournal Article
Year of Publication2022
AuthorsAja-Fernández, S., T. Pieciak, C. Martín-Martín, Á. Planchuelo-Gómez, R. de Luis-García, and A. Tristán-Vega
JournalMedical Image Analysis
Volume77
Pagination102356
ISSN1361-8415
KeywordsAMURA, Diffusion anisotropy, Fast acquisition, diffusion MRI, white matter
Abstract

AMURA (Apparent Measures Using Reduced Acquisitions) was originally proposed as a method to infer micro-structural information from single-shell acquisitions in diffusion MRI. It reduces the number of samples needed and the computational complexity of the estimation of diffusion properties of tissues by assuming the diffusion anisotropy is roughly independent on the b-value. This simplification allows the computation of simplified expressions and makes it compatible with standard acquisition protocols commonly used even in clinical practice. The present work proposes an extension of AMURA that allows the calculation of general moments of the diffusion signals that can be applied to describe the diffusion process with higher accuracy. We provide simplified expressions to analytically compute a set of scalar indices as moments of arbitrary orders over either the whole 3-D space, particular directions, or particular planes. The existing metrics previously proposed for AMURA (RTOP, RTPP and RTAP) are now special cases of this generalization. An extensive set of experiments is performed on public data and a clinical clase acquired with a standard type acquisition. The new metrics provide additional information about the diffusion processes inside the brain.

URLhttps://www.sciencedirect.com/science/article/pii/S1361841522000093
DOI10.1016/j.media.2022.102356