@article {909, title = {Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study}, journal = {Scientific Reports}, volume = {11}, year = {2021}, pages = {3846}, abstract = {

To date, two randomized, controlled studies support the use of candesartan for migraine prophylaxis but with limited external validity. We aim to evaluate the effectiveness and tolerability of candesartan in clinical practice and to explore predictors of patient response. Retrospective cohort study including all patients with migraine who received candesartan between April 2008-February 2019. The primary endpoint was the number of monthly headache days during weeks 8{\textendash}12 of treatment compared to baseline. Additionally, we evaluated the frequency during weeks 20{\textendash}24. We analysed the percentage of patients with 50\% and 75\% response rates and the retention rates after three and 6\ months of treatment. 120/4121 patients were eligible, aged 45.9 [11.5]; 100 (83.3\%) female. Eighty-four patients (70\%) had chronic migraine and 53 (42.7\%) had medication-overuse headache. The median number of prior prophylactics was 3 (Inter-quartile range 2{\textendash}5). At baseline, patients had 20.5 {\textpm} 8.5 headache days per month, decreasing 4.3 {\textpm} 8.4\ days by 3\ months (weeks 12{\textendash}16) and by 4.7 {\textpm} 8.7\ days by 6\ months (paired Student{\textquoteright}s t-test, p \< 0.001). The percentage of patients with a 50\% response was 32.5\% at 3\ months and 31.7\% at 6\ months, while the retention rate was 85.0\% and 58.3\%. The number of prior treatments (Odds ratio 0.79, 95\% CI 0.64{\textendash}0.97) and the presence of daily headache (Odds ratio 0.39, 95\% CI 0.16{\textendash}0.97) were associated with a lower probability of response. Candesartan showed beneficial effects in the preventive treatment of migraine in clinical practice, including patients with chronic migraine, medication-overuse headache and resistance to prior prophylactics.

}, issn = {2045-2322}, doi = {10.1038/s41598-021-83508-2}, url = {https://doi.org/10.1038/s41598-021-83508-2}, author = {S{\'a}nchez-Rodr{\'\i}guez, Carmen and Sierra, {\'A}lvaro and {\'A}lvaro Planchuelo-G{\'o}mez and Mart{\'\i}nez-P{\'\i}as, Enrique and {\'A}ngel L. Guerrero and Garc{\'\i}a-Azor{\'\i}n, David} } @conference {939, title = {Resting-state functional alterations in patients with persistent headache after COVID-19 infection: an exploratory study}, booktitle = {International Headache Congress 2021}, year = {2021}, month = {2021}, publisher = {International Headache Society \& European Headache Federation}, organization = {International Headache Society \& European Headache Federation}, address = {Virtual Congress}, abstract = {

Objective: To evaluate resting-state functional alterations in patients with persistent headache after COVID-19 resolution.
Methods: Exploratory case-control study. Highresolution brain resting-state functional Magnetic Resonance Imaging data were acquired in patients with
persistent headache after COVID-19 infection and healthy controls (HC). CONN toolbox (version 17) was employed to assess the resting-state functional connectivity between 84 cortical and subcortical gray matter regions of interest. Significant results were considered with p \< 0.05 (Family Discovery Rate and seed-level corrected).
Results: Ten patients with persistent headache after COVID-19 (mean age: 53.8 +- 7.8 years; nine women) and 10 HC balanced for age and sex (mean age: 51.9 +- 6.6 years; nine women) were included in the study. Statistically significant higher functional connectivity was observed in the patients with persistent headache compared to HC in 10 connections. These connections were composed of an occipital region and another region that included the isthmus cingulate gyrus, a frontal or a parietal area. In the patients, significant lower functional connectivity was found in 12 connections between the cingulate and hippocampal gyri, parietal, temporal and frontal regions.
Conclusions: Patients with persistent headache after COVID-19 infection present strengthened functional connectivity with occipital regions and weakened functional connectivity between frontal, temporal and parietal regions.

}, url = {https://journals.sagepub.com/doi/pdf/10.1177/03331024211034005}, author = {{\'A}lvaro Planchuelo-G{\'o}mez and Garc{\'\i}a-Azor{\'\i}n, David and {\'A}ngel L. Guerrero and Santiago Aja-Fern{\'a}ndez and Rodr{\'\i}guez, Margarita and Moro, Ra{\'u}l and Rodrigo de Luis-Garc{\'\i}a} } @article {903, title = {Response prediction for chronic migraine preventive treatment by gray matter morphometry in magnetic resonance imaging: a pilot study}, journal = {Revista de Neurologia}, volume = {71}, year = {2020}, pages = {399-406}, doi = {10.33588/rn.7111.2020488}, author = {{\'A}lvaro Planchuelo-G{\'o}mez and Garc{\'\i}a-Azor{\'\i}n, David and {\'A}ngel L. Guerrero and Santiago Aja-Fern{\'a}ndez and Ant{\'o}n-Juarros, Saray and Rodrigo de Luis-Garc{\'\i}a} } @article {menchon2019reconstruction, title = {Reconstruction techniques for cardiac cine MRI}, journal = {Insights into imaging}, volume = {10}, number = {1}, year = {2019}, pages = {100}, publisher = {Springer Berlin Heidelberg}, author = {Mench{\'o}n-Lara, Rosa-Mar{\'\i}a and Simmross-Wattenberg, Federico and Pablo Casaseca-de-la-Higuera and Mart{\'\i}n-Fern{\'a}ndez, Marcos and Alberola-L{\'o}pez, Carlos} } @proceedings {809, title = {Reduced Eddy Current induced image distortions and Peripheral Nerve Stimulation based on the Optimal Diffusion-weighting Gradient Waveform Design (ODGD) formulation}, volume = {3488}, year = {2019}, abstract = {

Diffusion-Weighted MRI (DW-MRI) often suffers from signal attenuation due to long TE, motion-related artefacts, dephasing due to concomitant gradients (CGs), and image distortions due to eddy currents (ECs). Further, the application of rapidly switching gradients may cause peripheral nerve stimulation (PNS). These challenges hinder the progress, application and interpretability of DW-MRI. Therefore, based on the Optimized Diffusion-weighting Gradient waveforms Design (ODGD) formulation, in this work we design optimal (minimum TE) nth-order moment-nulling diffusion-weighting gradient waveforms with or without CG-nulling able to reduce EC induced distortions and PNS-effects. We assessed the feasibility of these waveforms in simulations and phantom experiments.

}, author = {{\'O}scar Pe{\~n}a-Nogales and Yuxin Zhang and Rodrigo de Luis-Garc{\'\i}a and Santiago Aja-Fern{\'a}ndez and James H. Holmes and Diego Hernando} } @inbook {818, title = {Return-to-Axis Probability Calculation from Single-Shell Acquisitions}, booktitle = {Computational Diffusion MRI}, year = {2019}, pages = {29-41}, publisher = {Springer}, organization = {Springer}, isbn = {978-3-030-05830-2}, doi = {10.1007/978-3-030-05831-9_3}, author = {Santiago Aja-Fern{\'a}ndez and Antonio Trist{\'a}n-Vega and Molendowska, Malwina and Tomasz Pieciak and Luis-Garc{\'\i}a, Rodrigo} } @article {803, title = {Robust detection of audio-cough events using local Hu moments}, journal = {IEEE journal of biomedical and health informatics}, volume = {23}, year = {2019}, pages = {184{\textendash}196}, author = {Monge-{\'A}lvarez, Jes{\'u}s and Hoyos-Barcel{\'o}, Carlos and Lesso, Paul and Pablo Casaseca-de-la-Higuera} } @proceedings {759, title = {Return-to-the-origin probability calculation in single shell acquisitions}, year = {2018}, pages = {1414}, address = {Paris, France}, author = {Santiago Aja-Fern{\'a}ndez and Antonio Trist{\'a}n-Vega and Malwina Molendowska and Tomasz Pieciak and Rodrigo de Luis-Garc{\'\i}a} } @article {779, title = {Robust Estimation of the Apparent Diffusion Coefficient Invariant to Acquisition Noise and Physiological Motion}, journal = {Magnetic Resonance Imaging}, volume = {53}, year = {2018}, pages = {123-133}, abstract = {

In this work we have proposed a methodology for the estimation of the apparent diffusion coefficient in the body from multiple breath hold diffusion weighted images, which is robust to two preeminent confounding factors: noise and motion during acquisition. We have extended a method for the joint groupwise multimodal registration and apparent diffusion coefficient estimation, previously proposed by the authors, in order to correct the bias that arises from the non-Gaussianity of the data and the registration procedure. Results show that the proposed methodology provides a statistically significant improvement both in robustness for displacement fields calculation and in terms of accuracy for the apparent diffusion coefficient estimation as compared with traditional sequential approaches. Reproducibility has also been measured on real data in terms of the distribution of apparent diffusion coefficient differences obtained from different b-values subsets. Our proposal has shown to be able to effectively correct the estimation bias by introducing additional computationally light procedures to the original method, thus providing robust apparent diffusion coefficient maps in the liver and allowing an accurate and reproducible analysis of the tissue.

}, keywords = {Acquisition Noise, Apparent Diffusion Coefficient, Diffusion Weighted Imaging, Multimodal Groupwise Registration, Patient Movement Correction}, doi = {https://doi.org/10.1016/j.mri.2018.07.005}, url = {https://www.sciencedirect.com/science/article/pii/S0730725X18300687}, author = {Santiago Sanz-Est{\'e}banez and Tomasz Pieciak and Carlos Alberola-L{\'o}pez and Santiago Aja-Fern{\'a}ndez} } @conference {785, title = {Robust Windowed Harmonic Phase Analysis with a Single Acquisition}, booktitle = {MICCAI }, year = {2018}, month = {2018}, publisher = {MICCAI}, organization = {MICCAI}, address = {Granada}, abstract = {

The HARP methodology is a widely extended procedure for cardiac tagged magnetic resonance imaging since it is able to analyse local mechanical behaviour of the heart; extensions and improvements of this method have also been reported since HARP was released. Acquisition of an over-determined set of orientations is one of such alternatives,
which has notably increased HARP robustness at the price of increasing examination time. In this paper, we explore an alternative to this method based on the use of multiple peaks, as opposed to multiple orientations, intended for a single acquisition. Performance loss is explored with respect to multiple orientations in a real setting. In addition, we have assessed, by means of a computational phantom, optimal tag orientations and spacings of the stripe pattern by minimizing the Frobenius norm of the difference between the ground truth and the estimated material deformation gradient tensor. Results indicate that, for a single acquisition, multiple peaks as opposed to multiple orientations, are indeed preferable.

}, keywords = {Cardiac Tagged Magnetic Resonance Imaging, HARmonic Phase, Multi-Harmonic Analysis, Robust Strain Reconstruction}, author = {Santiago Sanz-Est{\'e}banez and Lucilio Cordero-Grande and Marcos Martin-Fern{\'a}ndez and Carlos Alberola L{\'o}pez} } @conference {aja2013robust, title = {Robust estimation of MRI myocardial perfusion parameters}, booktitle = {Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE}, year = {2013}, pages = {4382{\textendash}4385}, publisher = {IEEE}, organization = {IEEE}, author = {Santiago Aja-Fern{\'a}ndez and Lucilio Cordero-Grande and Gonzalo Vegas-S{\'a}nchez-Ferrero and Rodrigo de Luis-Garc{\'\i}a and Carlos Alberola-Lopez} } @proceedings {579, title = {Reconstrucci{\'o}n de la Se{\~n}al Respiratoria basada en Modelo Conjunto con la Se{\~n}al de Per{\'\i}odo Card{\'\i}aco}, year = {2012}, address = {San Sebasti{\'a}n, Spain}, author = {Diego Mart{\'\i}n-Mart{\'\i}nez and Pablo Casaseca-de-la-Higuera and Marcos Mart{\'\i}n-Fern{\'a}ndez and Carlos Alberola-Lopez} } @article {575, title = {Relation between Myocardial Infarction and Cyrcadian Rhythm in Patients Attended in a Prehospital Emergency Service}, journal = {Medicina Cl{\'\i}nica}, volume = {139}, year = {2012}, pages = {515-521}, chapter = {551}, author = {Barneto-Valero, Mar{\'\i}a Cristina and Jose Ramon Garmendia-Leiza and Julio Ardura-Fernández and Pablo Casaseca-de-la-Higuera and Jesus Maria Andres-de-Llano and Corral-Torres, Ervigio} } @conference {vegas2011realistic, title = {Realistic log-compressed law for ultrasound image recovery}, booktitle = {Image Processing (ICIP), 2011 18th IEEE International Conference on}, year = {2011}, pages = {2029{\textendash}2032}, publisher = {IEEE}, organization = {IEEE}, author = {Gonzalo Vegas-S{\'a}nchez-Ferrero and Diego Mart{\'\i}n-Mart{\'\i}nez and Pablo Casaseca-de-la-Higuera and Lucilio Cordero-Grande and Santiago Aja-Fern{\'a}ndez and Marcos Martin-Fernandez and Cesar Palencia} } @inbook {munoz2009review, title = {Review of techniques for registration of diffusion tensor imaging}, booktitle = {Tensors in Image Processing and Computer Vision}, year = {2009}, pages = {273{\textendash}297}, publisher = {Springer London}, organization = {Springer London}, author = {Emma Mu{\~n}oz-Moreno and Rub{\'e}n C{\'a}rdenes-Almeida and Marcos Martin-Fernandez} } @article {aja2008restoration, title = {Restoration of DWI data using a Rician LMMSE estimator}, journal = {Medical Imaging, IEEE Transactions on}, volume = {27}, number = {10}, year = {2008}, pages = {1389{\textendash}1403}, publisher = {IEEE}, author = {Santiago Aja-Fern{\'a}ndez and Niethammer, Marc and Kubicki, Marek and Martha E Shenton and Carl-Fredik Westin} } @article {422, title = {A radius and ulna TW3 bone age assessment system}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {55}, year = {2008}, pages = {1463-1476}, abstract = {

An end-to-end system to automate the well-known Tanner - Whitehouse (TW3) clinical procedure to estimate the skeletal age in childhood is proposed. The system comprises the detailed analysis of the two most important bones in TW3: the radius and ulna wrist bones. First, a modified version of an adaptive clustering segmentation algorithm is presented to properly semi-automatically segment the contour of the bones. Second, up to 89 features are defined and extracted from bone contours and gray scale information inside the contour, followed by some well-founded feature selection mathematical criteria, based on the ideas of maximizing the classes{\textquoteright} separability. Third, bone age is estimated with the help of a Generalized Softmax Perceptron (GSP) neural network (NN) that, after supervised learning and optimal complexity estimation via the application of the recently developed Posterior Probability Model Selection (PPMS) algorithm, is able to accurately predict the different development stages in both radius and ulna from which and with the help of the TW3 methodology, we are able to conveniently score and estimate the bone age of a patient in years, in what can be understood as a multiple-class (multiple stages) pattern recognition approach with posterior probability estimation. Finally, numerical results are presented to evaluate the system performance in predicting the bone stages and the final patient bone age over a private hand image database, with the help of the pediatricians and the radiologists expert diagnoses. {\^A}{\textcopyright} 2006 IEEE.

}, keywords = {Age Determination by Skeleton, Aging, Algorithms, Artificial Intelligence, Automated, Bone, Bone age assessment, Clustering algorithms, Computer-Assisted, Humans, Model selection, Neural networks, Pattern recognition, Radiographic Image Interpretation, Reproducibility of Results, Sensitivity and Specificity, Skeletal maturity, algorithm, article, artificial neural network, automation, bone age, bone maturation, childhood, instrumentation, radius, ulna}, issn = {00189294}, doi = {10.1109/TBME.2008.918554}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-42249094547\&partnerID=40\&md5=2cecfea5f75a61b048611f2391b00aed}, author = {Antonio Trist{\'a}n-Vega and J I Arribas} } @conference {417, title = {A radius and ulna skeletal age assessment system}, booktitle = {2005 IEEE Workshop on Machine Learning for Signal Processing}, year = {2005}, address = {Mystic, CT}, abstract = {

An end to end system to partially automate the TW3 bone age assessment procedure is proposed. The system comprises the detailed analysis of the two more important bones in TW3: the radius and ulna wrist bones. First, a generalization of K-means algorithm is presented to semi-automatically segment the contour of the bones and thus extract up to 89 features describing shapes and textures from bones. Second, a well-founded feature selection criterion based on the statistical properties of data is used in order to properly choose the most relevant features. Third, bone age is estimated with the help of a Generalized Softmax Perceptron (GSP) Neural Network (NN) whose optimal complexity is estimated via the Posterior Probability Model Selection (PPMS) algorithm. We can then predict the different development stages in both radius and ulna, from which we are able to score and estimate the bone age of a patient in years and finally we compare the NN results with those from the pediatrician expert discrepancies. {\^A}{\textcopyright} 2005 IEEE.

}, keywords = {Algorithms, Bone, Feature extraction, Generalized Softmax Perceptron (GSP), Living systems studies, Neural networks, Probability Model Selection (PPMS), Skeletal age assessment system}, isbn = {0780395174; 9780780395176}, doi = {10.1109/MLSP.2005.1532903}, url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33749052083\&partnerID=40\&md5=eefa29ac09f4efa304b613cf07ab8d10}, author = {Antonio Trist{\'a}n-Vega and J I Arribas} } @inbook {martin2003regularization, title = {Regularization of Diffusion Tensor Maps Using a Non-Gaussian Markov Random Field Approach}, booktitle = {Lecture Notes in Computer Science}, volume = {2879}, year = {2003}, pages = {92{\textendash}100}, publisher = {Berlin: Springer-Verlag}, organization = {Berlin: Springer-Verlag}, author = {Marcos Martin-Fernandez and Carlos Alberola-Lopez and Juan Ruiz-Alzola and Carl-Fredik Westin} } @conference {san2001reshaping, title = {Reshaping polygonal meshes with smoothed normals extracted from ultrasound volume data: An optimization approach}, booktitle = {Medical Imaging 2001}, year = {2001}, pages = {462{\textendash}472}, publisher = {International Society for Optics and Photonics}, organization = {International Society for Optics and Photonics}, author = {Raul San Jose-Estepar and Carlos Alberola-Lopez and Juan Ruiz-Alzola} } @proceedings {alberola1996region, title = {A Region Oriented CFAR Approach to the Detection of Extensive Targets in Textured Images}, year = {1996}, pages = {195}, publisher = {Elsevier Science Ltd}, author = {Carlos Alberola-Lopez and Casar-Corredera, Jos{\'e} Ramon and Juan Ruiz-Alzola} }