Optimal design of motion-compensated diffusion gradient waveforms
|Title||Optimal design of motion-compensated diffusion gradient waveforms|
|Publication Type||Conference Proceedings|
|Year of Conference||2017|
|Authors||Peña-Nogales, Ó., R. de Luís-Garcia, S. Aja-Fernández, Y. Zhang, J. H. Holmes, and D. Hernando|
|Conference Name||International Society of Magnetic Resonance in Medicine 25th Annual Meeting and Exhibition|
|Conference Location||Honolulu, HI, USA|
Diffusion-Weighted MRI (DW-MRI) often suffers from motion-related artifacts in organs that experience physiological motion. Importantly, organ motion during the application of diffusion gradients results in signal losses, which complicate image interpretation and bias quantitative measures. Motion-compensated gradient designs have been proposed, however they typically result in substantially lower b-values or severe concomitant gradient effects. In this work, we develop an approach for design of first- and second-order motion-compensated gradient waveforms based on a b-value maximization formulation including concomitant gradient nulling, and we compare it to existing techniques. The proposed design provides optimized b-values with motion compensation and concomitant gradient nulling.