Monte-Carlo Analysis of Quantitative Diffusion Measurements Using Motion-Compensated Diffusion Weighting Waveforms
|Monte-Carlo Analysis of Quantitative Diffusion Measurements Using Motion-Compensated Diffusion Weighting Waveforms
|Year of Conference
|Zhang, Y., Ó. Peña-Nogales, J. H. Holmes, and D. Hernando
|International Society of Magnetic Resonance in Medicine 25th Annual Meeting and Exhibition
|Honolulu, HI, USA
Advanced diffusion MRI acquisition strategies based on motion-compensated diffusion-econding waveforms have been proposed to reduce the signal voids caused by tissue motion. However, quantitative diffusion measurements obtained from these motion-compensated waveforms may be baised relative to standard monopolar gradient waveforms. This study evaluated the effect of different diffusion encoding gradient waveforms on the signal decay and diffusion measurements, using Monte-Carlo simulations with different microstructures and several reconstruction signal models. The results show substantial bias in observed signal decay and quantiative diffusion measurements in the same microstructure across different gradient waveforms, in the presence of restricted diffusion.