Cardiac MRI

Quantification of perfusion and viability of the myocardium.

Pharmacokinetic analysis based of perfusion MRI of the heart allows early detection and diagnosis of regional defects in myocardial irrigation which can subsequently lead to fibrosis or scarring of tissue. Delayed enhanced cardiac MRI can be used in this scenario —as well as for various types of heart disease— to know the transmural extent damaged tissue, resulting of great interest for therapeutic decision making.

We have developed a set of methods to segment the myocardium, correct the misalignment of the sequences due to patient breathing and to robustly estimate the pharmacokinetic model parameters. In order to quantify the transmurality of the lesson, an initial segmentation of the scarred tissue is obtained. Our developed methods calculate simultaneously the thickness both of the scar and the healthy myocardium. 3D maps of local transmurality are obtained from the calculated values.

It provides a comprehensive tool for pharmacokinetic analysis of myocardial perfusion and the transmural scar tissue from magnetic resonance, for which there are no solutions on the market nowadays.

 

Papers

  • Royuela-del-Val, J., M. Usman, L. Cordero-Grande, F. Simmross-Wattenberg, M. Martin-Fernández, C. Prieto, and C. Alberola-López, "Single Breath Hold Whole Heart Cine MRI With Iterative Groupwise Cardiac Motion Compensation and Sparse Regularization (kt-WiSE)", Proceedings of the International Society for Magnetic Resonance in Medicine 23, 2015.
  • Cordero-Grande, L., J. Royuela-del-Val, M. Martin-Fernandez, and C. Alberola-López, "MOWHARP: Multi-Oriented Windowed HARP Reconstruction for Robust Strain Imaging", Proceedings of the International Society for Magnetic Resonance in Medicine 22, 2014.
  • Merino-Caviedes, S., L. Cordero-Grande, A. Sevilla- Ru Revilla-Orodea, M.. T. Perez, M. Martin-Fernandez, and C. Alberola-López, "Multi-stencil streamline fast marching: a general 3D framework to determine myocardial thickness and transmurality in late enhancement images", Medical Imaging, IEEE Transactions on, vol. 33, pp. 23–37, 2014.
  • Cordero-Grande, L., T. Sevilla, A. Revilla, M. Martin-Fernandez, and C. Alberola-López, "Assessment of the fibrotic myocardial tissue mechanics by image processing", Computing in Cardiology Conference (CinC), 2013: IEEE, 2013.
  • Merino-Caviedes, S., L. Cordero-Grande, T. Sevilla, T. Pérez, M. Martin-Fernandez, and C. Alberola-López, "Classification of delayed enhancement scar islands by means of their local subendocardial transmurality", Computing in Cardiology Conference (CinC), 2013: IEEE, 2013.
  • Cordero-Grande, L., S. Merino-Caviedes, S. Aja-Fernández, and C. Alberola-López, "Groupwise elastic registration by a new sparsity-promoting metric: application to the alignment of cardiac magnetic resonance perfusion images", Pattern Analysis and Machine Intelligence, IEEE Transactions on, vol. 35, no. 11: IEEE, pp. 2638–2650, 2013.
  • Cordero-Grande, L., M. Martin-Fernandez, and C. Alberola-López, "Integration of biomechanical properties in a Markov random field: Application to myocardial motion estimation in cardiomyopathy patients", Quantitative Medical Imaging: Optical Society of America, pp. QW2G–1, 2013.
  • Cordero-Grande, L., G. Vegas-Sanchez-Ferrero, P. Casaseca-de-la-Higuera, S. Aja-Fernández, and C. Alberola-López, "A magnetic resonance software simulator for the evaluation of myocardial deformation estimation", Medical engineering & physics, vol. 35, no. 9: Elsevier, pp. 1331–1340, 2013.
  • Aja-Fernández, S., L. Cordero-Grande, G. Vegas-Sanchez-Ferrero, R. de Luis-Garcia, and C. Alberola-López, "Robust estimation of MRI myocardial perfusion parameters", Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE: IEEE, pp. 4382–4385, 2013.
  • Cordero-Grande, L., S. Merino-Caviedes, X. Alba, RM. Figueras i Ventura, A. F. Frangi, and C. Alberola-López, "3D fusion of cine and late-enhanced cardiac magnetic resonance images", Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on: IEEE, pp. 286–289, 2012.
  • Díaz-Rodríguez, JM., L. Cordero-Grande, M. Martin-Fernandez, and C. Alberola-López, "Detección automática del ventr{ículo derecho en imágenes de resonancia magnética cardiaca 3D", CASEIB2012, San Sebastián, Espana, 2012.
  • Cordero-Grande, L., G. Vegas-Sanchez-Ferrero, P. Casaseca-de-la-Higuera, and C. Alberola-López, "A Markov random field approach for topology-preserving registration: Application to object-based tomographic image interpolation", Image Processing, IEEE Transactions on, vol. 21, no. 4: IEEE, pp. 2047–2061, 2012.
  • Aja-Fernández, S., L. Cordero-Grande, and C. Alberola-López, "A MRI phantom for cardiac perfusion simulation", Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on: IEEE, pp. 638–641, 2012.
  • Cordero-Grande, L., S. Merino-Caviedes, R. de Luis-Garcia, S. Aja-Fernández, M. Martin-Fernandez, and C. Alberola-López, "Groupwise myocardial alignment in magnetic resonance perfusion sequences", Proc of the XXIX CASEIB, Cáceres, Spain, pp. 437–440, 2011.
  • Cordero-Grande, L., G. Vegas-Sanchez-Ferrero, P. Casaseca-de-la-Higuera, and C. Alberola-López, "Improving Harmonic Phase Imaging by the Windowed Fourier Transform", Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on: IEEE, pp. 520–523, 2011.
  • Cordero-Grande, L., G. Vegas-Sanchez-Ferrero, P. Casaseca-de-la-Higuera, and C. Alberola-López, "Topology-preserving registration: a solution via graph cuts", Combinatorial Image Analysis: Springer, pp. 420–431, 2011.
  • Merino-Caviedes, S., L. Cordero-Grande, T. M Pérez, and M. Martin-Fernandez, "Transmurality Maps in Late Enhancement Cardiac Magnetic Resonance Imaging by a New Radial Fast Marching Method", XXIX Congreso Anual de la Sociedad Española de Ingeniería Biomédica, Cáceres, Spain, pp. 211–214, 2011.
  • Cordero-Grande, L., G. Vegas-Sanchez-Ferrero, P. Casaseca-de-la-Higuera, A. J San-Román-Calvar, A. Revilla-Orodea, M. Martin-Fernandez, and C. Alberola-López, "Unsupervised 4D myocardium segmentation with a Markov Random Field based deformable model", Medical image analysis, vol. 15, no. 3: Elsevier, pp. 283–301, 2011.
  • Vegas-Sanchez-Ferrero, G., A. Tristán-Vega, L. Cordero-Grande, P. Casaseca-de-la-Higuera, S. Aja-Fernández, M. Martin-Fernandez, and C. Alberola-López, "Strain Rate Tensor estimation in cine cardiac MRI based on elastic image registration", Computer Vision and Pattern Recognition Workshops, 2008. CVPRW'08. IEEE Computer Society Conference on: IEEE, pp. 1–6, 2008.